Research
Doctoral program Clinical Pharmacy
The doctoral program Clinical Pharmacy is an interdisciplinary institution at the LMU Klinikum München. The doctoral projects deal with the topic of drug therapy safety in various patient groups. The foundation Patient & Clinical Pharmacy supports research projects and the annual symposia, among other things.
Influence of concomitant medication on side effects of checkpoint inhibitor therapy
As part of a translational research project, the hospital pharmacy and the Department of Medical II of the University Hospital Augsburg are investigating the influence of non-oncological concomitant medication on immune-related adverse events (irAE) and the response to therapy with checkpoint inhibitors. Data from cancer patients with solid tumours are analysed retrospectively. Prospectively, a structured drug history is also taken in order to be able to analyse potential influences on the immune profile and therapy response in a more targeted manner with a high level of data quality. The aim is to identify risk factors for irAE, improve treatment decisions and develop strategies for effective side effect management.
Improved antibiotic dosing for surgical procedures
Cefazolin is widely used around the world to prevent surgical site infections. However, the standard practice of administering a single dose at the start of a procedure does not always result in sufficiently effective blood levels, and in some patients, it can even lead to an overdose. This project systematically investigates the concentration of the antibiotic in cardiac and neurosurgical patients and develops a model to determine which dose offers the best protection against wound infection. The goal is to provide better protection against wound infections, safer antibiotic therapy, and a scientific basis for future treatment recommendations.
